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α-Synuclein forms non-selective cation channels and stimulates ATP-sensitive potassium channels in hippocampal neurons
In Parkinson's disease and several other neurodegenerative diseases, the protein α-synuclein (αS) is produced within neurons and accumulates in the extracellular fluid. Several mechanisms of αS action are proposed, one of which is the formation of cation-permeable pores that may mediate toxicit...
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| Vydáno v: | J Physiol |
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| Hlavní autor: | |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
BlackWell Publishing Ltd
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4293060/ https://ncbi.nlm.nih.gov/pubmed/25556793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.280974 |
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