Indole-3-carbinol inhibits tumorigenicity of hepatocellular carcinoma cells via suppression of microRNA-21 and upregulation of phosphatase and tensin homolog

A major obstacle to successful treatment of hepatocellular carcinoma (HCC) is its high resistance to cytotoxic chemotherapy due to overexpression of multidrug resistance genes. Activation of the AKT pathway is known to be involved in chemoresistance in HCC; however, the underlying mechanisms modulat...

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Udgivet i:Biochim Biophys Acta
Main Authors: Wang, Xinmei, He, Hongyan, Lu, Yuanzhi, Ren, Wei, Teng, Kun-yu, Chiang, Chi-ling, Yang, Zhaogang, Yu, Bo, Hsu, Shuhao, Jacob, Samson T., Ghoshal, Kalpana, Lee, L. James
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4293016/
https://ncbi.nlm.nih.gov/pubmed/25447674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2014.10.017
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