Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor

BACKGROUND AND PURPOSE: Naturally occurring single-nucleotide polymorphisms (SNPs) within GPCRs can result in alterations in various pharmacological parameters. Understanding the regulation and function of endocytic trafficking of the μ-opioid receptor (MOP receptor) is of great importance given its...

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Foilsithe in:Br J Pharmacol
Main Authors: Cooke, A E, Oldfield, S, Krasel, C, Mundell, S J, Henderson, G, Kelly, E
Formáid: Artigo
Teanga:Inglês
Foilsithe: Blackwell Publishing Ltd 2015
Ábhair:
Themed Section: Opioids: New Pathways to Functional Selectivity
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292971/
https://ncbi.nlm.nih.gov/pubmed/24697554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12709
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