Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

INTRODUCTION: Accumulating evidence suggests an important role for interleukin 17 (IL-17) in the pathogenesis of several inflammatory diseases, including rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Accordingly, clinical trials aimed at blocking IL-17 have been initiated, but clinical re...

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Опубликовано в: :Arthritis Res Ther
Главные авторы: van Baarsen, Lisa GM, Lebre, Maria C, van der Coelen, Dennis, Aarrass, Saïda, Tang, Man W, Ramwadhdoebe, Tamara H, Gerlag, Daniëlle M, Tak, Paul P
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
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Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4292832/
https://ncbi.nlm.nih.gov/pubmed/25146432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-014-0426-z
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