Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors

[Image: see text] From a virtual screening starting point, inhibitors of the serum and glucocorticoid regulated kinase 1 were developed through a combination of classical medicinal chemistry and library approaches. This resulted in highly active small molecules with nanomolar activity and a good ove...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Halland, Nis, Schmidt, Friedemann, Weiss, Tilo, Saas, Joachim, Li, Ziyu, Czech, Jörg, Dreyer, Matthias, Hofmeister, Armin, Mertsch, Katharina, Dietz, Uwe, Strübing, Carsten, Nazare, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291729/
https://ncbi.nlm.nih.gov/pubmed/25589934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5003376
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