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Adaptor-mediated Lon proteolysis restricts Bacillus subtilis hyperflagellation

The Lon AAA+ protease is a highly conserved intracellular protease that is considered an anticancer target in eukaryotic cells and a crucial virulence regulator in bacteria. Lon degrades both damaged, misfolded proteins and specific native regulators, but how Lon discriminates among a large pool of...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mukherjee, Sampriti, Bree, Anna C., Liu, Jing, Patrick, Joyce E., Chien, Peter, Kearns, Daniel B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291670/
https://ncbi.nlm.nih.gov/pubmed/25538299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417419112
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