In Vitro Activity of wALADin Benzimidazoles against Different Life Cycle Stages of Plasmodium Parasites

wALADin1 benzimidazoles are specific inhibitors of δ-aminolevulinic acid dehydratase from Wolbachia endobacteria of filarial nematodes. We report that wALADin1 and two derivatives killed blood stage Plasmodium falciparum in vitro (50% inhibitory concentrations, 39, 7.7, and 12.8 μM, respectively). O...

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Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Lentz, Christian S., Sattler, Julia M., Fendler, Martina, Gottwalt, Simon, Halls, Victoria S., Strassel, Silke, Arriens, Sandra, Hannam, Jeffrey S., Specht, Sabine, Famulok, Michael, Mueller, Ann-Kristin, Hoerauf, Achim, Pfarr, Kenneth M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2014
Gaiak:
Experimental Therapeutics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291411/
https://ncbi.nlm.nih.gov/pubmed/25313210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02383-14
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