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A Hybrid Cationic Peptide Composed of Human β-Defensin-1 and Humanized θ-Defensin Sequences Exhibits Salt-Resistant Antimicrobial Activity

We have designed a hybrid peptide by combining sequences of human β-defensin-1 (HBD-1) and θ-defensin, in an attempt to generate a molecule that combines the diversity in structure and biological activity of two different peptides to yield a promising therapeutic candidate. HBD-1 was chosen as it is...

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Bibliografske podrobnosti
izdano v:Antimicrob Agents Chemother
Main Authors: Olli, Sudar, Nagaraj, Ramakrishnan, Motukupally, Swapna R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291353/
https://ncbi.nlm.nih.gov/pubmed/25348533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03901-14
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