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TRANSCRIPTION FACTORS WITH CONSERVED BINDING SITES NEAR ATOH1 ON THE POU4F3 GENE ENHANCE THE INDUCTION OF COCHLEAR HAIR CELLS

Overexpression of the transcription factor (TF) ATOH1 is known to induce the transformation of nonsensory cells in the organ of Corti into hair cells (HCs). Evaluating DNA 5′ to the coding sequence of the pou4f3 gene, a target of ATOH1 in HCs, we identified in three regions containing clustered bind...

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Pubblicato in:Mol Neurobiol
Autori principali: Ikeda, Ryoukichi, Pak, Kwang, Chavez, Eduardo, Ryan, Allen F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291311/
https://ncbi.nlm.nih.gov/pubmed/25015561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-014-8801-y
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