HDAC Inhibitor-Mediated Beta-Cell Protection Against Cytokine-Induced Toxicity Is STAT1 Tyr701 Phosphorylation Independent

Histone deacetylase (HDAC) inhibition protects pancreatic beta-cells against apoptosis induced by the combination of the proinflammatory cytokines interleukin (IL)-1β and interferon (IFN)-γ. Decreased expression of cell damage-related genes is observed on the transcriptional level upon HDAC inhibiti...

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Veröffentlicht in:J Interferon Cytokine Res
Hauptverfasser: Dahllöf, Mattias S., Christensen, Dan P., Harving, Mette, Wagner, Bridget K., Mandrup-Poulsen, Thomas, Lundh, Morten
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2015
Schlagworte:
Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291159/
https://ncbi.nlm.nih.gov/pubmed/25062500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2014.0022
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