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Mathematical modeling of postmenopausal osteoporosis and its treatment by the anti-catabolic drug denosumab
Denosumab, a fully human monoclonal antibody, has been approved for the treatment of postmenopausal osteoporosis. The therapeutic effect of denosumab rests on its ability to inhibit osteoclast differentiation. Here, we present a computational approach on the basis of coupling a pharmacokinetics mode...
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| Publicado no: | Int J Numer Method Biomed Eng |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4291103/ https://ncbi.nlm.nih.gov/pubmed/24039120 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cnm.2584 |
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