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FiberDock: Flexible induced-fit backbone refinement in molecular docking

Upon binding, proteins undergo conformational changes. These changes often prevent rigid-body docking methods from predicting the 3D structure of a complex from the unbound conformations of its proteins. Handling protein backbone flexibility is a major challenge for docking methodologies, as backbon...

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Bibliografische gegevens
Gepubliceerd in:Proteins
Hoofdauteurs: Mashiach, Efrat, Nussinov, Ruth, Wolfson, Haim J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2010
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4290165/
https://ncbi.nlm.nih.gov/pubmed/20077569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.22668
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