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Transgenic Increase in n-3/n-6 Fatty Acid Ratio Protects Against Cognitive Deficits Induced by an Immune Challenge through Decrease of Neuroinflammation

Polyunsaturated fatty acids (PUFAs) display immunomodulatory properties in the brain, n-3 PUFAs being able to reduce inflammation whereas n-6 PUFAs are more pro-inflammatory. It has been extensively demonstrated that exposure to a peripheral immune challenge leads to the production and release of in...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Delpech, Jean-Christophe, Madore, Charlotte, Joffre, Corinne, Aubert, Agnès, Kang, Jing Xuan, Nadjar, Agnès, Layé, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289942/
https://ncbi.nlm.nih.gov/pubmed/25228141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2014.196
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