Methylxanthine Inhibit Fungal Chitinases and Exhibit Antifungal Activity

Chitinases are necessary for fungal cell wall remodeling and cell replication. Methylxanthines have been shown to competitively inhibit family 18 chitinases in vitro. We sought to determine the effects of methylxanthines on fungal chitinases. Fungi demonstrated variable chitinase activity and incuba...

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Bibliographic Details
Published in:Mycopathologia
Main Authors: Tsirilakis, Kalliope, Kim, Christy, Vicencio, Alfin G., Andrade, Christopher, Casadevall, Arturo, Goldman, David L.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289597/
https://ncbi.nlm.nih.gov/pubmed/21968902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11046-011-9483-x
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