Human breast cancer and lymph node metastases express Gb3 and can be targeted by STxB-vectorized chemotherapeutic compounds

BACKGROUND: The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on primary colon carcinoma specimen. METHODS: Using a novel ex vivo STxB labeling...

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Foilsithe in:BMC Cancer
Main Authors: Stimmer, Lev, Dehay, Sabrina, Nemati, Fariba, Massonnet, Gerald, Richon, Sophie, Decaudin, Didier, Klijanienko, Jerzy, Johannes, Ludger
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289340/
https://ncbi.nlm.nih.gov/pubmed/25476116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-916
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