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Insights into the species-specific TLR4 signaling mechanism in response to Rhodobacter sphaeroides lipid A detection
TLR4 in complex with MD2 senses the presence of lipid A (LA) and initiates a signaling cascade that curb the infection. This complex is evolutionarily conserved and can initiate the immune system in response to a variety of LAs. In this study, molecular dynamics simulation (25 ns) was performed to e...
Enregistré dans:
| Publié dans: | Sci Rep |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4288214/ https://ncbi.nlm.nih.gov/pubmed/25563849 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep07657 |
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