A pilot phase II Study of digoxin in patients with recurrent prostate cancer as evident by a rising PSA

BACKGROUND: Digoxin was found to inhibit prostate cancer (PCa) growth via the inhibition of HIF-1α synthesis in a mouse model. We hypothesized that a therapeutic dose of digoxin could inhibit human PCa growth and disease progression. METHODS: An open label, single arm pilot study was performed. Pati...

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Publicado en:Am J Cancer Ther Pharmacol
Main Authors: Lin, Jianqing, Zhan, Tingting, Duffy, Danielle, Hoffman-Censits, Jean, Kilpatrick, Deborah, Trabulsi, Edouard J., Lallas, Costas D., Chervoneva, Inna, Limentani, Kimberly, Kennedy, Brooke, Kessler, Sarah, Gomella, Leonard, Antonarakis, Emmanuel S., Carducci, Michael A., Force, Thomas, Kelly, Wm. Kevin
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287984/
https://ncbi.nlm.nih.gov/pubmed/25580468
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