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Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice
Insulin-like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic administration of recombinant IGF2 enhances memory. Here, using a gene therapy-based approach with adeno-associated virus (AAV), we show that IGF2 over...
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Publicado no: | EMBO Mol Med |
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Principais autores: | , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
BlackWell Publishing Ltd
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4287930/ https://ncbi.nlm.nih.gov/pubmed/25100745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404228 |
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