Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability

Fatty acid synthase (FAS) is altered in metabolic disorders and cancer. Conventional FAS null mice die in utero so effects of whole body inhibition of lipogenesis following development are unknown. Inducible global knockout of FAS (iFASKO) in mice was lethal due to a disrupted intestinal barrier and...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Metab
Hauptverfasser: Lodhi, Irfan J., Wei, Xiaochao, Yin, Li, Feng, Chu, Adak, Sangeeta, Abou-Ezzi, Grazia, Hsu, Fong-Fu, Link, Daniel C., Semenkovich, Clay F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287274/
https://ncbi.nlm.nih.gov/pubmed/25565205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.12.002
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