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Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability
Fatty acid synthase (FAS) is altered in metabolic disorders and cancer. Conventional FAS null mice die in utero so effects of whole body inhibition of lipogenesis following development are unknown. Inducible global knockout of FAS (iFASKO) in mice was lethal due to a disrupted intestinal barrier and...
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| 發表在: | Cell Metab |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4287274/ https://ncbi.nlm.nih.gov/pubmed/25565205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.12.002 |
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