Designed Transcription Activator-Like Effector Proteins Efficiently Induced the Expression of Latent HIV-1 in Latently Infected Cells

HIV latency is the foremost barrier to clearing HIV infection from patients. Reactivation of latent HIV-1 represents a promising strategy to deplete these viral reservoirs. Here, we report a novel approach to reactivate latent HIV-1 provirus using artificially designed transcription activator-like e...

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Bibliographic Details
Published in:AIDS Res Hum Retroviruses
Main Authors: Wang, Xiaohui, Wang, Pengfei, Fu, Zheng, Ji, Haiyan, Qu, Xiying, Zeng, Hanxian, Zhu, Xiaoli, Deng, Junxiao, Lu, Panpan, Zha, Shijun, Song, Zhishuo, Zhu, Huanzhang
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2015
Subjects:
Preclinical Studies/Drug Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4287188/
https://ncbi.nlm.nih.gov/pubmed/25403229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2014.0121
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