Neuronal Development in Caenorhabditis elegans Is Regulated by Inhibition of an MLK MAP Kinase Pathway

We show that loss-of-function mutations in kinases of the MLK-1 pathway (mlk-1, mek-1, and kgb-1/jnk) function cell-autonomously in neurons to suppress defects in synapse formation and axon termination caused by rpm-1 loss of function. Our genetic analysis also suggests that the phosphatase PPM-1, l...

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Detalhes bibliográficos
Publicado no:Genetics
Main Authors: Baker, Scott T., Turgeon, Shane M., Tulgren, Erik D., Wigant, Jeanne, Rahimi, Omeed, Opperman, Karla J., Grill, Brock
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2015
Assuntos:
Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286679/
https://ncbi.nlm.nih.gov/pubmed/25339611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.170589
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