The Role of Small Heterodimer Partner (SHP) in NAFLD Improvement after Vertical Sleeve Gastrectomy in Mice

OBJECTIVE: Bile acids (BA) are elevated after vertical sleeve gastrectomy (VSG) and farnesoid-X-receptor (FXR) is critical to the success of murine VSG. BA down-regulate hepatic lipogenesis by activating the FXR-small heterodimer partner (SHP) pathway. We tested the role of SHP in fatty liver diseas...

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Veröffentlicht in:Obesity (Silver Spring)
Hauptverfasser: Myronovych, Andriy, Salazar-Gonzales, Rosa-Maria, Ryan, Karen K., Miles, Lili, Zhang, Wujuan, Jha, Pinky, Wang, Li, Setchell, Kenneth DR, Seeley, Randy J, Kohli, Rohit
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4286402/
https://ncbi.nlm.nih.gov/pubmed/25376397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.20890
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