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Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice.

The murine Ca(2+)-stimulated adenylyl cyclase (type I) (EC 4.6.1.1), which is expressed predominantly in brain, was inactivated by targeted mutagenesis. Ca(2+)-stimulated adenylyl cyclase activity was reduced 40-60% in the hippocampus, neocortex, and cerebellum. Long-term potentiation in the CA1 reg...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Wu, Z L, Thomas, S A, Villacres, E C, Xia, Z, Simmons, M L, Chavkin, C, Palmiter, R D, Storm, D R
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1995
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42849/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7816821/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.1.220
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