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Identification of the xenosensors regulating human 5-aminolevulinate synthase

Heme is an essential component of numerous hemoproteins with functions including oxygen transport, energy metabolism, and drug biotransformation. In nonerythropoietic cells, 5-aminolevulinate synthase (ALAS1) is the rate-limiting enzyme in heme biosynthesis. Upon exposure to drugs that induce cytoch...

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Detalhes bibliográficos
Main Authors: Podvinec, Michael, Handschin, Christoph, Looser, Renate, Meyer, Urs A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC428484/
https://ncbi.nlm.nih.gov/pubmed/15178759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401845101
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