A neurokinin 1 receptor antagonist decreases postoperative peritoneal adhesion formation and increases peritoneal fibrinolytic activity

Fibrous adhesions remain a major sequela of abdominal surgery. The proinflammatory peptide substance P (SP), known to participate in inflammatory events, may play a key role in adhesion formation. This hypothesis was tested by using an antagonist, CJ-12,255 (Pfizer), that blocks the binding of SP to...

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Bibliographische Detailangaben
Hauptverfasser: Reed, Karen L., Fruin, A. Brent, Gower, Adam C., Stucchi, Arthur F., Leeman, Susan E., Becker, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC428482/
https://ncbi.nlm.nih.gov/pubmed/15187234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0403210101
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