Glutamatergic regulation prevents hippocampal-dependent age-related cognitive decline through dendritic spine clustering

The dementia of Alzheimer’s disease (AD) results primarily from degeneration of neurons that furnish glutamatergic corticocortical connections that subserve cognition. Although neuron death is minimal in the absence of AD, age-related cognitive decline does occur in animals as well as humans, and it...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pereira, Ana C., Lambert, Hilary K., Grossman, Yael S., Dumitriu, Dani, Waldman, Rachel, Jannetty, Sophia K., Calakos, Katina, Janssen, William G., McEwen, Bruce S., Morrison, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284552/
https://ncbi.nlm.nih.gov/pubmed/25512503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1421285111
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