Nitric oxide represses inhibitory κB kinase through S-nitrosylation

Nitric oxide (NO) possesses antiinflammatory effects, which may be exerted via its ability to inhibit the transcription factor, NF-κB. A commonly proposed mode of action for inhibition of NF-κBbyNO involves interference with NF-κB binding to DNA. Because activation of inhibitory κB kinase (IKK), the...

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Main Authors: Reynaert, Niki L., Ckless, Karina, Korn, Solange H., Vos, Nanda, Guala, Amy S., Wouters, Emiel F. M., van der Vliet, Albert, Janssen-Heininger, Yvonne M. W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC428452/
https://ncbi.nlm.nih.gov/pubmed/15184672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400588101
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