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Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits

Inhibition of myosin phosphatase is critical for agonist-induced contractility of vascular smooth muscle. The protein CPI-17 is a phosphorylation-dependent inhibitor of myosin phosphatase and, in response to agonists, Thr-38 is phosphorylated by protein kinase C, producing a >1,000-fold increase...

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Библиографические подробности
Главные авторы: Eto, Masumi, Kitazawa, Toshio, Brautigan, David L.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC428442/
https://ncbi.nlm.nih.gov/pubmed/15184667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0307812101
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