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Optimal designs for composed models in pharmacokinetic–pharmacodynamic experiments
We consider two frequently used PK/PD models and provide closed form descriptions of locally optimal designs for estimating individual parameters. In a novel way, we use these optimal designs and construct locally standardized maximin optimal designs for estimating any subset of the model parameters...
Gorde:
| Argitaratua izan da: | J Pharmacokinet Pharmacodyn |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2012
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4284081/ https://ncbi.nlm.nih.gov/pubmed/22614634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10928-012-9251-7 |
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