AMPA/kainate glutamate receptors contribute to inflammation, degeneration and pain related behaviour in inflammatory stages of arthritis

OBJECTIVES: Synovial fluid glutamate concentrations increase in arthritis. Activation of kainate (KA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptors (GluRs) increase interleukin-6 (IL-6) release and cause arthritic pain, respectively. We hypothesised that AMPA an...

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Detalhes bibliográficos
Publicado no:Ann Rheum Dis
Main Authors: Bonnet, Cleo S, Williams, Anwen S, Gilbert, Sophie J, Harvey, Ann K, Evans, Bronwen A, Mason, Deborah J
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2015
Assuntos:
Basic and Translational Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283694/
https://ncbi.nlm.nih.gov/pubmed/24130267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2013-203670
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