Comparative genomic analysis of tumors: detection of DNA losses and amplification.

We demonstrate the use of representational difference analysis for cloning probes that detect DNA loss and amplification in tumors. Using DNA isolated from human tumor cell lines to drive hybridization against matched normal DNA, we were able to identify six genomic regions that are homozygously del...

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Main Authors: Lisitsyn, N A, Lisitsina, N M, Dalbagni, G, Barker, P, Sanchez, C A, Gnarra, J, Linehan, W M, Reid, B J, Wigler, M H
格式: Artigo
語言:Inglês
出版: 1995
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC42835/
https://ncbi.nlm.nih.gov/pubmed/7816807
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