The Level of Circulating Octanoate Does Not Predict Ghrelin O-Acyl Transferase (GOAT)-Mediated Acylation of Ghrelin During Fasting

BACKGROUND: Acyl-ghrelin is a 28-amino acid peptide released from the stomach. Ghrelin O-acyl transferase (GOAT) attaches an 8-carbon medium-chain fatty acid (MCFA) (octanoate) to serine 3 of ghrelin. This acylation is necessary for the activity of ghrelin. Animal data suggest that MCFAs provide sub...

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Bibliografske podrobnosti
izdano v:J Clin Endocrinol Metab
Main Authors: Nass, Ralf, Nikolayev, Alexander, Liu, Jianhua, Pezzoli, Suzan S., Farhy, Leon S., Patrie, James, Gaylinn, Bruce D., Heiman, Mark, Thorner, Michael O.
Format: Artigo
Jezik:Inglês
Izdano: Endocrine Society 2015
Teme:
JCEM Online: Brief Reports
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4283022/
https://ncbi.nlm.nih.gov/pubmed/25337923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2014-1318
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