Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma

Midline pediatric high-grade astrocytomas (pHGAs) are incurable with few treatment targets identified. Most tumors harbor K27M mutations on histone 3 variants. In 40 treatment-naïve midline pHGAs, 39 analyzed by whole-exome sequencing, we find additional somatic mutations specific to tumor location....

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Publicado no:Nat Genet
Main Authors: Fontebasso, Adam M., Papillon-Cavanagh, Simon, Schwartzentruber, Jeremy, Nikbakht, Hamid, Gerges, Noha, Fiset, Pierre-Olivier, Bechet, Denise, Faury, Damien, De Jay, Nicolas, Ramkissoon, Lori, Corcoran, Aoife, Jones, David T W, Sturm, Dominik, Johann, Pascal, Tomita, Tadanori, Goldman, Stewart, Nagib, Mahmoud, Bendel, Anne, Goumnerova, Liliana, Bowers, Daniel C., Leonard, Jeffrey R., Rubin, Joshua B., Alden, Tord, Browd, Samuel, Geyer, J. Russell, Leary, Sarah, Jallo, George, Cohen, Kenneth, Gupta, Nalin, Prados, Michael D., Carret, Anne-Sophie, Ellezam, Benjamin, Crevier, Louis, Klekner, Almos, Bognar, Laszlo, Hauser, Peter, Garami, Miklos, Myseros, John, Dong, Zhifeng, Siegel, Peter M., Malkin, Hayley, Ligon, Azra, Albrecht, Steffen, Pfister, Stefan M., Ligon, Keith L., Majewski, Jacek, Jabado, Nada, Kieran, Mark W
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282994/
https://ncbi.nlm.nih.gov/pubmed/24705250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2950
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