Alpha-tryptase gene variation is associated with levels of circulating IgE and lung function in asthma

BACKGROUND: Tryptase, a major secretory product of human mast cells has been implicated as a key mediator of allergic inflammation. Genetic variation in the tryptases is extensive, and α-tryptase, an allelic variant of the more extensively studied β-tryptase, is absent in substantial numbers of the...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Clin Exp Allergy
Main Authors: Abdelmotelb, A M, Rose-Zerilli, M J, Barton, S J, Holgate, S T, Walls, A F, Holloway, J W
Format: Artigo
Jezik:Inglês
Izdano: BlackWell Publishing Ltd 2013
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282335/
https://ncbi.nlm.nih.gov/pubmed/24372627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cea.12259
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