A randomized phase II study of cediranib alone versus cediranib in combination with dasatinib in docetaxel resistant, castration resistant prostate cancer patients

BACKGROUND: Activation of the vascular endothelial growth factor receptor (VEGFR) and the oncogenic Src pathway has been implicated in the development of castration-resistant prostate cancer (CRPC) in preclinical models. Cediranib and dasatinib are multi-kinase inhibitors targeting VEGFR and Src res...

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Foilsithe in:Invest New Drugs
Main Authors: Spreafico, Anna, Chi, Kim N., Sridhar, Srikala S., Smith, David C., Carducci, Michael A., Kavsak, Peter, Wong, Tracy S., Wang, Lisa, Ivy, S. Percy, Mukherjee, Som Dave, Kollmannsberger, Christian K., Sukhai, Mahadeo A., Takebe, Naoko, Kamel-Reid, Suzanne, Siu, Lillian L., Hotte, Sebastien J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2014
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281773/
https://ncbi.nlm.nih.gov/pubmed/24788563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0106-5
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