Discovery of Mycobacterium tuberculosis α-1,4-Glucan Branching Enzyme (GlgB) Inhibitors by Structure- and Ligand-based Virtual Screening

GlgB (α-1,4-glucan branching enzyme) is the key enzyme involved in the biosynthesis of α-glucan, which plays a significant role in the virulence and pathogenesis of Mycobacterium tuberculosis. Because α-glucans are implicated in the survival of both replicating and non-replicating bacteria, there ex...

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Udgivet i:J Biol Chem
Main Authors: Dkhar, Hedwin Kitdorlang, Gopalsamy, Anupriya, Loharch, Saurabh, Kaur, Amandeep, Bhutani, Isha, Saminathan, Kanmani, Bhagyaraj, Ella, Chandra, Vemika, Swaminathan, Kunchithapadam, Agrawal, Pushpa, Parkesh, Raman, Gupta, Pawan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2015
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281769/
https://ncbi.nlm.nih.gov/pubmed/25384979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589200
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