α-Actinin 4 Potentiates Nuclear Factor κ-Light-chain-enhancer of Activated B-cell (NF-κB) Activity in Podocytes Independent of Its Cytoplasmic Actin Binding Function

Glomerular podocytes are highly specialized terminally differentiated cells that act as a filtration barrier in the kidney. Mutations in the actin-binding protein, α-actinin 4 (ACTN4), are linked to focal segmental glomerulosclerosis (FSGS), a chronic kidney disease characterized by proteinuria. Abe...

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Vydáno v:J Biol Chem
Hlavní autoři: Zhao, Xuan, Hsu, Kuo-Sheng, Lim, Jun Hee, Bruggeman, Leslie A., Kao, Hung-Ying
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281736/
https://ncbi.nlm.nih.gov/pubmed/25411248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597260
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