The Ubiquitin-associated (UBA) Domain of SCCRO/DCUN1D1 Protein Serves as a Feedback Regulator of Biochemical and Oncogenic Activity

Amplification of squamous cell carcinoma-related oncogene (SCCRO) activates its function as an oncogene in a wide range of human cancers. The oncogenic activity of SCCRO requires its potentiating neddylation domain, which regulates its E3 activity for neddylation. The contribution of the N-terminal...

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Vydáno v:J Biol Chem
Hlavní autoři: Huang, Guochang, Towe, Christopher W., Choi, Lydia, Yonekawa, Yoshihiro, Bommeljé, Claire C., Bains, Sarina, Rechler, Willi, Hao, Bing, Ramanathan, Yegnanarayana, Singh, Bhuvanesh
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281733/
https://ncbi.nlm.nih.gov/pubmed/25411243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.560169
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