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The Influenza Hemagglutinin Fusion Domain Is an Amphipathic Helical Hairpin That Functions by Inducing Membrane Curvature

The highly conserved N-terminal 23 residues of the hemagglutinin glycoprotein, known as the fusion peptide domain (HAfp23), is vital to the membrane fusion and infection mechanism of the influenza virus. HAfp23 has a helical hairpin structure consisting of two tightly packed amphiphilic helices that...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Principais autores: Smrt, Sean T., Draney, Adrian W., Lorieau, Justin L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281724/
https://ncbi.nlm.nih.gov/pubmed/25398882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611657
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