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SEARS: A Seamless Dose Escalation/Expansion with Adaptive Randomization Scheme
BACKGROUND: Standard drug development conducts phase I dose finding and phase II dose expansion sequentially and separately. Information between the two phases is rarely shared. Administratively, such a sequential process is time consuming and burdensome. PURPOSE: We propose SEARS, a seamless design...
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| Publicado no: | Clin Trials |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4281526/ https://ncbi.nlm.nih.gov/pubmed/24137041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774513500081 |
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