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Inhibition of tumor-associated αvβ3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo

A more complete understanding of the mechanisms that regulate the angiogenic switch, which contributes to the conversion of small dormant tumors to actively growing malignancies, is important for the development of more effective anti-angiogenic strategies for cancer therapy. While significant progr...

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Bibliografiske detaljer
Udgivet i:Angiogenesis
Main Authors: Contois, Liangru W., Akalu, Abebe, Caron, Jennifer M., Tweedie, Eric, Cretu, Alexandra, Henderson, Terry, Liaw, Lucy, Friesel, Robert, Vary, Calvin, Brooks, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281512/
https://ncbi.nlm.nih.gov/pubmed/25249331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10456-014-9445-2
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