Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model

We tested the hypothesis that Lipofectamine siRNA delivery to deplete transient receptor potential cation channel (TRPC) 1 protein expression can suppress hypoxia-induced pulmonary arterial hypertension (PAH) in mice. Adult male C57BL/6 mice were equally divided into group 1 (normal controls), group...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Sun, Cheuk-Kwan, Zhen, Yen-Yi, Lu, Hung-I, Sung, Pei-Hsun, Chang, Li-Teh, Tsai, Tzu-Hsien, Sheu, Jiunn-Jye, Chen, Yung-Lung, Chua, Sarah, Chang, Hsueh-Wen, Chen, Yi-Ling, Lee, Fan-Yen, Yip, Hon-Kan
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281407/
https://ncbi.nlm.nih.gov/pubmed/25587286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/316214
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