Mirror-Image Organometallic Osmium Arene Iminopyridine Halido Complexes Exhibit Similar Potent Anticancer Activity

Four chiral Os(II) arene anticancer complexes have been isolated by fractional crystallization. The two iodido complexes, (S(Os),S(C))-[Os(η(6)-p-cym)(ImpyMe)I]PF(6) (complex 2, (S)-ImpyMe: N-(2-pyridylmethylene)-(S)-1-phenylethylamine) and (R(Os),R(C))-[Os(η(6)-p-cym)(ImpyMe)I]PF(6) (complex 4, (R)...

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Publicado no:Chemistry
Main Authors: Fu, Ying, Soni, Rina, Romero, María J, Pizarro, Ana M, Salassa, Luca, Clarkson, Guy J, Hearn, Jessica M, Habtemariam, Abraha, Wills, Martin, Sadler, Peter J
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280897/
https://ncbi.nlm.nih.gov/pubmed/24114923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201302183
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