Structural and functional studies of Bud23–Trm112 reveal 18S rRNA N(7)-G1575 methylation occurs on late 40S precursor ribosomes

The eukaryotic small ribosomal subunit carries only four ribosomal (r) RNA methylated bases, all close to important functional sites. N(7)-methylguanosine (m(7)G) introduced at position 1575 on 18S rRNA by Bud23–Trm112 is at a ridge forming a steric block between P- and E-site tRNAs. Here we report...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Létoquart, Juliette, Huvelle, Emmeline, Wacheul, Ludivine, Bourgeois, Gabrielle, Zorbas, Christiane, Graille, Marc, Heurgué-Hamard, Valérie, Lafontaine, Denis L. J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2014
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280632/
https://ncbi.nlm.nih.gov/pubmed/25489090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1413089111
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