TIMP-1 creates a pre-metastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice

Due to its ability to inhibit pro-metastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)-1 has been thought to suppress tumor metastasis. However, elevated systemic levels of TIMP-1 correlate with poor prognosis in cancer patients suggesting a metastasis-stimulating role...

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Detalhes bibliográficos
Publicado no:Hepatology
Main Authors: Seubert, Bastian, Grünwald, Barbara, Kobuch, Julia, Cui, Haissi, Schelter, Florian, Schaten, Susanne, Siveke, Jens T., Lim, Ngee H., Nagase, Hideaki, Simonavicius, Nicole, Heikenwalder, Mathias, Reinheckel, Thomas, Sleeman, Jonathan P., Janssen, Klaus-Peter, Knolle, Percy A., Krüger, Achim
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280301/
https://ncbi.nlm.nih.gov/pubmed/25131778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.27378
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