Increasing membrane cholesterol of neurons in culture recapitulates Alzheimer’s disease early phenotypes

BACKGROUND: It is suspected that excess of brain cholesterol plays a role in Alzheimer’s disease (AD). Membrane-associated cholesterol was shown to be increased in the brain of individuals with sporadic AD and to correlate with the severity of the disease. We hypothesized that an increase of membran...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Marquer, Catherine, Laine, Jeanne, Dauphinot, Luce, Hanbouch, Linda, Lemercier-Neuillet, Camille, Pierrot, Nathalie, Bossers, Koen, Le, Mickael, Corlier, Fabian, Benstaali, Caroline, Saudou, Frédéric, Thinakaran, Gopal, Cartier, Nathalie, Octave, Jean-Noël, Duyckaerts, Charles, Potier, Marie-Claude
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4280040/
https://ncbi.nlm.nih.gov/pubmed/25524049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-9-60
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