A Novel Atypical Hemolytic Uremic Syndrome–Associated Hybrid CFHR1/CFH Gene Encoding a Fusion Protein That Antagonizes Factor H–Dependent Complement Regulation

Genomic aberrations affecting the genes encoding factor H (FH) and the five FH-related proteins (FHRs) have been described in patients with atypical hemolytic uremic syndrome (aHUS), a rare condition characterized by microangiopathic hemolytic anemia, thrombocytopenia, and ARF. These genomic rearran...

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Detalles Bibliográficos
Publicado en:J Am Soc Nephrol
Autores principales: Valoti, Elisabetta, Alberti, Marta, Tortajada, Agustin, Garcia-Fernandez, Jesus, Gastoldi, Sara, Besso, Luca, Bresin, Elena, Remuzzi, Giuseppe, Rodriguez de Cordoba, Santiago, Noris, Marina
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Nephrology 2015
Materias:
Clinical Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279739/
https://ncbi.nlm.nih.gov/pubmed/24904082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013121339
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