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Inhibition of Akt with small molecules and biologics: historical perspective and current status of the patent landscape
INTRODUCTION: Akt plays a pivotal role in cell survival and proliferation through a number of downstream effectors; unregulated activation of the PI3K/PTEN/Akt pathway is a prominent feature of many human cancers. Akt is considered an attractive target for cancer therapy by the inhibition of Akt alo...
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| Publié dans: | Expert Opin Ther Pat |
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| Auteurs principaux: | , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4279453/ https://ncbi.nlm.nih.gov/pubmed/21635152 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543776.2011.587959 |
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