Simultaneous targeting of PI3Kδ and a PI3Kδ-dependent MEK1/2-Erk1/2 pathway for therapy in pediatric B-cell acute lymphoblastic leukemia

B cell acute lymphoblastic leukemia (B-ALL) is the most common hematological malignancy diagnosed in children, and blockade of the abnormally activated PI3Kδ displayed promising outcomes in B cell acute or chronic leukemias, but the mechanisms are not well understood. Here we report a novel PI3Kδ se...

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Publicat a:Oncotarget
Autors principals: Wang, Xiang, Zhang, Xi, Li, Ben-shang, Zhai, Xiaowen, Yang, Zhuo, Ding, Li-xia, Wang, Hongsheng, Liang, Chris, Zhu, Weiliang, Ding, Jian, Meng, Ling-hua
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2014
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279406/
https://ncbi.nlm.nih.gov/pubmed/25313141
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