The induction of the p53 tumor suppressor protein bridges the apoptotic and autophagic signaling pathways to regulate cell death in prostate cancer cells

The p53 tumor suppressor protein plays a crucial role in influencing cell fate decisions in response to cellular stress. As p53 elicits cell cycle arrest, senescence or apoptosis, the integrity of the p53 pathway is considered a key determinant of anti-tumor responses. p53 can also promote autophagy...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Ringer, Lymor, Sirajuddin, Paul, Tricoli, Lucas, Waye, Sarah, Choudhry, Muhammad Umer, Parasido, Erika, Sivakumar, Angiela, Heckler, Mary, Naeem, Aisha, Abdelgawad, Iman, Liu, Xuefeng, Feldman, Adam S., Lee, Richard J., Wu, Chin-Lee, Yenugonda, Venkata, Kallakury, Bhaskar, Dritschilo, Anatoly, Lynch, John, Schlegel, Richard, Rodriguez, Olga, Pestell, Richard G., Avantaggiati, Maria Laura, Albanese, Chris
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279402/
https://ncbi.nlm.nih.gov/pubmed/25296977
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